Other Unintended effects not outlined might also come about in certain clients. In the event you observe some other effects, Check out with your Health care Expert.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals less than six several years of age, mainly because The mix may well result in deadly respiratory melancholy Within this age population. It can be crucial that promethazine hydrochloride and codeine phosphate syrup is measured with an correct measuring system (see PRECAUTIONS-Data for Patients).
Promethazine is nicely absorbed within the gastrointestinal tract. Clinical outcomes are evident within twenty minutes right after oral administration and usually last 4 to six hours, While They could persist provided that 12 several hours.
Reduce Seizure Threshold - Promethazine may perhaps decrease seizure threshold. It should be applied with caution in individuals with seizure disorders or in individuals who are making use of concomitant prescription drugs, for example narcotics or area anesthetics, which can also impact seizure threshold.
Actavis Promethazine Code will likely aid with a sore throat from allergic reactions and provides you aid from your headache That always will come When you've got a cold.
amiodarone will improve the degree or outcome of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Keep an eye on. Helps prevent conversion of actavis promethazine with codeine codeine to its Lively metabolite morphine.
Pregnancy. Promethazine/codeine could induce harm to an unborn little one. Tell your healthcare supplier Should you be or prepare to become pregnant. Your healthcare company will suggest you if you ought to get promethazine/codeine when you are Expecting or attempting to get Expecting.
Bone marrow suppression can result in infections or bleeding. This can be significant as well as everyday living-threatening. Keep all appointments to possess your blood checked. Inform your healthcare supplier immediately In case you have any of the subsequent symptoms of bone marrow suppression.
Using Alcoholic beverages or tobacco with particular medicines might also cause interactions to happen. The subsequent interactions are already picked on The premise of their possible importance and are not necessarily all-inclusive.
People who find themselves 65 and more mature is often at greater chance for some Unwanted side effects from promethazine/codeine. Speak with your healthcare company about your threats If you're With this age team.
To assist protect against withdrawal, your medical doctor may well lower your dose bit by bit. Withdrawal is a lot more likely if you have utilised this medication for many years (more than a few weeks) or in higher doses. Inform your medical professional or pharmacist immediately For those who have withdrawal.
Your pharmacist can show you the entire elements in the specific promethazine/codeine products and solutions they inventory.
Having said that, codeine needs to be administered only underneath close supervision to individuals with a history of drug abuse or dependence.
The mixture of these features brought about a substantial shift in The provision of Actavis cough syrup and reflected broader issues bordering opioid medicines.